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KMID : 0358819840110020169
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1984 Volume.11 No. 2 p.169 ~ p.176
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OSTEOGENESIS INDUCED BY IMPLANTATION OF DECALCIFIED HOMOGENOUS AND HETEROGENOUS BONES IN RATS
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Koo Soon-Sang
Lee Jong-Won
Lee Taik-Ho
Shin Tai-Sun
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Abstract
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The most effective osseous graft material is the fresh autogenous bone in clinical practice and experimental studies.
However, there are some problems in use of fresh autogenous bone graft, such as donor-site morbidity and the limitation in amount of available autogenous bone.
Since the introduction of decalcified bone as grafting material by Senn(1889), decalcified bone has been studied as substitute for autogenous bone. The implantation of decalcified bone segment or powder in soft tissue has been established as a laboratory model for studying bone induction.
Bone powders (particle size: 74∼420㎛) of rat and ox were decalcified with 0.5M HCI and were implanted i rat’s abdomen subcutaneously. Thereafter, periodic observation was made histologically up to 30 days. Comparative studies were carried out to determine differences in histological sequence of induced osteogenesis and quantity of new bone.
The results were as follows;
1. Implantation of decalcified bone powders of rat and ox to subcutaneous site in rats resulted in new bone formation by an enchondral sequence and there were no differences in histological change periodically.
2. There were no differences in quantity of new bone.
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KEYWORD
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